Inflammation and Weight Loss: What is the Relation?

There is a complex relationship between inflammation and weight loss. Inflammation increases with weight gain, which can lead to leptin and insulin resistance. So, reducing inflammation is essential if you’re looking to lose weight.

In this article, we’ll explore the relationship between inflammation and weight loss, and what you can do to reduce it.

Statistics on Inflammation


Obesity is a risk factor for chronic inflammation, which contributes to the development of chronic diseases like diabetes, heart disease, and cancer. According to the World Obesity Federation, 80% of individuals with type 2 diabetes and 70% of individuals with cardiovascular disease are overweight or obese.

Weight Loss

Losing weight reduces inflammation, particularly in adipose tissue, otherwise known as fat tissue. For example, a recent study found that a 5% to 10% reduction in body weight can significantly reduce inflammation in obese individuals.


Diet has a significant impact on your levels of inflammation. A study published in the American Journal of Clinical Nutrition found that a diet high in processed foods and refined carbohydrates was associated with higher levels of inflammation, while one rich in fruits, vegetables, whole grains, and healthy fats was associated with lower levels of inflammation.

You can reduce inflammation by avoiding processed foods and added sugars, eating more anti-inflammatory foods, getting enough sleep, and decreasing stress levels.


Regular exercise reduces inflammation levels, particularly in individuals who are obese or overweight. A study published in the Journal of Applied Physiology found that regular exercise can reduce inflammation in fat tissue and improve insulin sensitivity in obese individuals.

Disorders Related to Inflammation and Obesity

To put the importance of inflammation and weight loss into context, here are some common issues related to obesity and inflammatory states:

Obesity is often linked to:

Systemic Inflammation (SCI) can lead to diseases like:

  • Cardiovascular disease
  • Diabetes
  • Autoimmune conditions
  •  Neurodegenerative disorders

Systemic inflammation also increases your risk for metabolic issues like:

  • Hypertension
  • Hyperglycemia (extra sugars in the blood)
  • Dyslipidemia (a lot of fats in the blood)

What is Metaflammation?

Metaflammation is the metabolic inflammatory state that is often associated with obesity. It directly contributes to insulin resistance, metabolic syndrome, and type 2 diabetes.

Metaflammation is typically defined by low-grade, chronic inflammation in metabolic tissues, which can include:

  • Adipose (fat) cells
  • Brain
  • Liver
  • Pancreas

Weight loss and calorie restriction will decrease inflammation and increase insulin sensitivity. This is especially true in people medically advised to lose weight.

How is Obesity Related to Inflammation?

The discovery that systemic inflammation is a significant health factor has only recently been discovered. Researchers are still working to comprehend the different mechanisms and implications of exactly how obesity triggers inflammation. Although still uncertain, the process involves an immediate response from the immune system.

Inflammation induced by obesity represents a rapid and focused response to a site of injury or infection by the innate immune system. This is your program responsible for fighting infection and keeping your body safe.

However, unlike the defensive inflammatory response meant to fight off infection, the inflammation from obesity does not resolve without intervention. This makes it a risk for becoming chronic when not appropriately addressed.

How does this work?

1.   Specialized metabolic cells (adipose or fat cells) immediately work to maintain the injury and begin the inflammatory process. This disrupts the metabolic homeostasis

2.   The immune system recognizes the damage and sends a group of inflammatory cytokines.

3.   These cytokines travel to fat cells as well as the liver, pancreas, brain, and muscle tissues.

4.   More immune cells infiltrate metabolic tissues. This includes cells like natural killer cells (NT) and macrophages.

5.   Changes appear in the population of adipose cells. There’s a decrease in regulatory T cells, which favors further immune activation.

Gut Inflammation

When it comes to weight gain, gut inflammation can contribute significantly. This is why many dietary interventions are geared toward gut health, promoting pre- and probiotics. Thus, a balanced diet with fresh fruit and vegetables is essential for gut health.

Elevated Lipids

Poor diet and obesity can contribute to elevated levels of lipids. These contribute to the pathology of weight gain by driving cellular infiltration of pro-inflammatory macrophages. It should also be noted that other lipids, such as omega-3 and omega-6, have anti-inflammatory properties.

Can Inflammation Cause Weight Gain?

Systematic inflammation can make people more prone to insulin resistance, type 2 diabetes, and cardiovascular disease. This causes easier weight gain and more challenging weight loss.

Specific subgroups of the population, like people with rheumatoid arthritis (a chronic condition caused by systematic inflammation), are more susceptible to insulin resistance and metabolic disorder. People with these conditions must better understand how to manage a balanced diet and active lifestyle. This can be the key to preventing obesity and inflammation.

Inflammation knocks the equilibrium in your body out of balance. A healthy lifestyle is critical to returning the body to health and homeostasis.

Adding extra weight to your frame often leads to more inflammation. It will also cause a cascade of hormones that will disrupt your body’s hunger signaling.

Choosing the Right Diet to Fight Inflammation

Whether or not certain types of food will reduce inflammation depends on the person and their complete dietary approach.

People tend to eat in patterns, and an imbalanced and heavily processed diet is often the cause of inflammation. However, certain foods will work to decrease inflammation.

In this case, Omega-3 and Omega-6 decrease inflammation by correcting the imbalance of lipids in your body. In addition, certain other foods may also reduce inflammation due to the presence of polyphenols.

Polyphenols are a particular class of compounds found in many plant foods, including flavonoids, phenolic acids, lignans, and stilbenes. Currently, there are more than 8,000 different types of polyphenols that have been identified.

Foods that Fight Inflammation

  • Olive oil
  • Coffee
  • Green leafy vegetables like spinach, kale, and chard
  • Nuts like cashews, almonds, and walnuts
  • Fatty fish like tuna, salmon, mackerel, and sardines
  • Fruit like cherries, strawberries, blueberries, bananas, and oranges

Foods that Increase Inflammation

  • Refined carbs, like white bread, white rice, and pastries
  • Soda and other sugar-sweetened beverages
  • French fries, chips, and other fried foods

Fiber Plays a Role

Good bacteria will help fight inflammation, and the stuff in your gut particularly affects chronic inflammation. In addition, gut bacteria produce essential nutrients for your body, including short-chain fatty acids that will feed the cells in your colon.

A diet high in fiber leads to reduced gut inflammation and improvements in related inflammatory disorders. Chronic, long-term inflammation is a serious condition that can even attack your body’s own tissues. It also plays a significant role in chronic Western diseases, including Alzheimer’s, heart disease, and metabolic syndrome.

Several studies have shown that a high-fiber diet is linked to lower levels of inflammatory markers in the bloodstream.

Summing it Up

More inflammation is correlated to obesity and weight gain, just as less inflammation is connected to weight loss. The two conditions are inextricably linked. If you want to see a decrease in inflammation and issues caused by it, the first step is changing your diet and exercise. This starts with healthy foods high in fiber and avoiding inflammatory factors like processed foods and unnecessary sugar. The more you follow these guidelines, the less inflammation you’ll experience and the more improvements you’ll see.


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Lomaira™ (phentermine hydrochloride USP) 8 mg tablets, CIV is a prescription medicine used for a short period of time (a few weeks) for weight reduction and should be used together with regular exercise and a reduced-calorie diet. Lomaira is for adults with an initial BMI* of 30 or more (obese) or 27 or more (overweight) with at least one weight-related medical condition such as controlled high blood pressure, diabetes, or high cholesterol. The limited usefulness of this drug class (anorectics), including Lomaira, should be measured against possible risk factors inherent in their use.

Don’t take Lomaira™ if you have a history of cardiovascular disease (e.g., coronary artery disease, stroke, arrhythmias, congestive heart failure or uncontrolled high blood pressure); are taking or have taken a monoamine oxidase inhibitor drug (MAOI) within the past 14 days; have overactive thyroid, glaucoma (increased pressure in the eyes), agitation or a history of drug abuse; are pregnant, nursing, or allergic to the sympathomimetic amines such as phentermine or any of the ingredients in Lomaira.

Taking phentermine with other drugs for weight loss is not recommended. Primary pulmonary hypertension (PPH), a rare fatal lung disease, has been reported in patients who had taken a combination of phentermine and fenfluramine or dexfenfluramine for weight loss. The possible association between phentermine use alone and PPH cannot be ruled out. Patients should report immediately if they experience any decrease in the amount of exercise that they can normally tolerate, shortness of breath, chest or heart pain, fainting or swelling in the lower legs.

Serious heart valve problems or disease have been reported in patients taking a combination of phentermine and fenfluramine or dexfenfluramine for weight loss. The possible role of phentermine has not been established, therefore the possibility of an association between heart valve disease and the use of phentermine alone cannot be ruled out.

If your body becomes adjusted to the maximum dose of phentermine so that its effects are experienced less strongly, the maximum dose should not be exceeded in an attempt to increase the effect.

Caution is advised when engaging in potentially hazardous activity such as driving or operating machinery while taking phentermine. Phentermine has the potential to be abused. Keep Lomaira in a safe place to prevent theft, accidental overdose, misuse or abuse. Using alcohol with phentermine may result in an adverse drug reaction.

Phentermine can cause an increase in blood pressure. Tell your doctor if you have high blood pressure, even if it’s mild. If you are taking medicines for type 2 diabetes, your doctor may have to adjust these medicines while taking phentermine.

Some side effects of phentermine that have been reported include pulmonary hypertension, valvular heart disease, palpitations, increased heart rate or blood pressure, insomnia, restlessness, dry mouth, diarrhea, constipation and changes in sexual drive. These are not all of the potential side effects of phentermine. For more information, ask your doctor or pharmacist.

To report negative side effects of prescription drugs, contact FDA at 1-800-FDA-1088 or visit

*Body Mass Index (BMI) measures the amount of fat in the body based on height and weight. BMI is measured in kg/m2.

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IMPORTANT SAFETY INFORMATION Don’t take Lomaira™ if you have a history of cardiovascular disease (e.g., coronary artery disease, stroke, arrhythmias, congestive heart failure or uncontrolled high blood pressure); are taking or have taken a monoamine oxidase inhibitor drug (MAOI) within the past 14 days; have overactive thyroid, glaucoma (increased pressure in the eyes), agitation or a history of drug abuse; are pregnant, nursing, or allergic to the sympathomimetic amines such as phentermine or any of the ingredients in Lomaira.